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  2. 基本情報公開
  3. 専任教員一覧 [医療技術学部]
  4. 磯 達也

基本情報公開

専任教員一覧

医療技術学部
  1. TOP
  2. 基本情報公開
  3. 専任教員一覧 [医療技術学部]
  4. 磯 達也
磯 達也
ISO TATSUYA
教授
所　属 群馬医療福祉大学　医療技術学部　医療技術学科　臨床工学専攻
最終学歴・学位 群馬大学医学部卒業（1990)
医学博士(2002)
専門・研究分野 循環器内科学（専門医）、心臓病学、分子生物学、代謝学
資格 医師免許（1990）
研究テーマ 循環器内科学、心臓病学、血管生物学
分子生物学
代謝学
心不全、腎不全
研究キーワード 脂肪酸、グルコース、代謝、分子生物学、心不全、腎不全
研究業績・著書
・論文、その他
それに準じる業績		 （著書）
Iso T, Kurabayashi M. Fatty Acid Uptake by the Heart During Fasting. (Chapter 8) Effects of undernutrition: general aspects, organs and tissue systems. Handbook of Famine, Starvation, and Nutrient Deprivation (edited by Preedy and Patel). 2017: 1-20. Springer International Publishing.
（学術論文）
1． Umbarawan Y, Kawakami R, Syamsunarno MRAA, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Koitabashi N, Sunaga H, Matsui H, Kurabayashi M, Iso T. Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice. Metabolites. 2021 Dec 17;11(12):881. (corresponding author)
2． Harada T, Araki T, Sunaga H, Kagami K, Yoshida K, Kato T, Kawakami R, Tomono J, Wada N, Iso T, Kurabayashi M, Obokata M. Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction. Sci Rep. 2021 Oct 27;11:21175.
3． Kawakami R, Matsui M, Konno A, Kaneko R, Shrestha S, Shrestha S, Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M, Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, Hirai H, Kurabayashi M, Iso T. Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury. J Pathol. 2021 Dec;255(4):362-373. (corresponding author)
4． Kagami K, Sunaga H, Sorimachi H, Harada T, Yoshida K, Kato T, Kurosawa K, Kawakami R, Koitabashi N, Iso T, Adachi T, Kurabayashi M, Obokata M. Prognostic impact of elevated fatty acid-binding protein 1 in patients with heart failure. ESC Heart Fail. 2021 Apr;8(2):1494-1501. doi: 10.1002/ehf2.13239. Epub 2021 Feb 4.
5． Umbarawan Y, Enoura A, Ogura H, Sato T, Horikawa M, Ishii T, Sunaga H, Matsui H, Yokoyama T, Kawakami R, Maeno T, Setou M, Kurabayashi M, Iso T. FABP5 is a sensitive marker for lipid-rich macrophages in luminal side of atherosclerosis. Int Heart J. 2021 May 29;62(3):666-676. (corresponding author)
6． Umbarawan Y, Kawakami R, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sunaga H, Matsui H, Kurabayashi M, Iso T. Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy.
Sci Rep. 2020 Nov 30;10(1):20809. (corresponding author)
7． Iso T, Haruyama H, Sunaga H, Matsui M, Matsui H, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Yokoyama T, Kurabayashi M. Exercise endurance capacity ismarkedly reduced due to impaired energy homeostasis during prolonged fasting inFABP4/5 deficient mice. BMC Physiol. 2019 Mar 13;19(1):1. (corresponding author)
8． Shrestha S, Sunaga H, Hanaoka H, Yamaguchi A, Kuwahara S, Umbarawan Y, Nakajima K, Machida T, Murakami M, Saito A, Tsushima Y, Kurabayashi M, Iso T. Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. Sci Rep. 2018 Nov 6;8(1):16451. (corresponding author)
9． Iso T, Haruyama H, Sunaga H, Matsui H, Matsui M, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Putri M, Yamaguchi A, Hanaoka H, Negishi K, Yokoyama T, Kurabayashi M. CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting. Physiol Rep. 2018 Sep;6(19):e13884. (corresponding author)
10． Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure. Sci Rep. 2018 Aug 13;8(1):12035. (corresponding author)
11． Umbarawan Y, Mas Rizky AA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid binding protein-4 and -5 knockout mice. Cardiovasc Res. 2018 Jul 1;114(8):1132-1144. (corresponding author)
12． Umbarawan Y, Syamsunarno MRAA, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice. Metabolism. 2017 Dec;77:47-57. (corresponding author)
13． Iso T, Sunaga H, Matsui H, Kasama S, Oshima N, Haruyama H, Furukawa N, Nakajima K, Machida T, Murakami M, Yokoyama T, Kurabayashi M. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise. Clinical Biochemistry. 2017 Nov;50(16-17):896-902. (corresponding author)
14． Obokata M, Iso T (equal contributor), Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, Iizuka T, Fukuda N, Takamatsu H, Koitabashi N, Funada R, Takama N, Kasama S, Kaneko Y, Yokoyama T, Murakami M, Kurabayashi M. Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction. Eur Heart J Acute Cardiovas Care. 2018 Sep;7(6):561-569.
25744081.
15． Iso T, Kurabayashi M. Extremely Low Levels of Serum Uric Acid Are Associated with Endothelial Dysfunction in Humans. Circ J. 2015 Apr 24;79(5):978-80. (editorial comment)
16． Putri M, Syamsunarno MRAA, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Biochem Biophys Res Commun. 2015 Feb 20;457(4):520-5. (corresponding author)
17． Syamsunarno MRAA, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, Sunaga H, Koitabashi N, Matsui H, Maeda K, Endo K, Tsushima Y, Yokoyama T, Kurabayashi M.Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. PLoS One. 2014 Mar 6;9(6):e90825. (corresponding author)
18． Syamsunarno MRAA, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto, K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One 2013, Nov 14;8(11):e79386. (corresponding author)
19． Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MRAA, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, Hotamisligil GS,Kurabayashi M. Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle. Arterioscler Thromb Vasc Biol. 2013; Nov;33(11):2549-2557. (corresponding author)　
20． Goto K, Iso T (equal contributor), Hanaoka H, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MRAA, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M. PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting. J Am Heart Assoc. 2013 Jan 18;2(1):e004861. (corresponding author)
（総説）
英文
1． Iso T, Kurabayashi M. Cardiac Metabolism and Contractile Function in Mice with Reduced Trans-Endothelial Fatty Acid Transport. Metabolites. 2021 Dec 19;11(12):889. (corresponding author)
2． Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003; 194:237-55.
3． Iso T, Hamamori Y, Kedes L. Notch signaling in vascular development.
Arterioscler Thromb Vasc Biol. 2003;23:543-53.
和文
4． 磯達也「心筋エネルギー基質変換の病態生理的意義」、心臓（日本心臓財団）2020; 52(2); 201-209.
5． 磯達也「心臓エネルギー代謝と圧負荷ストレス応答」、循環器内科（科学評論社）2019; 85(3); 312-319.
6． 磯達也「心臓の脂肪酸取り込み機構の全容とその障害が心機能に及ぼす影響」、循環器内科（科学評論社）2017; 81(5); 476-482.
7． 磯達也、倉林正彦、「毛細血管内皮細胞を介する心筋・骨格筋の脂肪酸代謝の制御機構と全身代謝への影響」、Annual Review 2015 糖尿病・代謝・内分泌（中外医学社）2015; 98-104.
8． 磯達也、倉林正彦、「毛細血管内皮細胞を介する脂肪酸代謝の制御機構とPPARgの役割」、内分泌・糖尿病・代謝内科（科学評論社）2014; 39 (6); 449-454.
9． 磯達也、倉林正彦 、「筋型毛細血管内皮細胞を介する心筋脂肪酸代謝の制御機構」、月刊 細胞（ニューサイエンス社）2014; 46 (7); 303-306.
10． 磯達也、「Notchシグナル」、血管新生研究の最先端（医薬ジャーナル社）2013 Feb; 119-125.
受　賞 2014年 第５回　Molecular Cardiovascular Conference II Best Abstract賞
2004年 第２回日本心臓財団動脈硬化Update、最優秀賞
2004年 第９回心血管病研究助成、最優秀賞
2003年 第８回心血管病研究助成、優秀賞
2002年 A finalist of Young Investigator Award
XIIth International Vascular Biology Meeting in Karuizawa
2000年 A Finalist of Young Investigator Award
American Heart Association, Western State Affiliate
2000年 A Finalist of Young Investigator Award
American College of Cardiology in Anaheim
1999年 Fellowship from American Heart Association, Western State Affiliate
主な学会活動 日本内科学会、日本循環器学会、国際心臓研究学会、日本血管生物学会、日本生理学会
社会等との関わり 科学研究費委員会専門員、国際心臓研究学会（評議員）、International Heart Journal (editorial board)、Frontiers in Cardiovascular Medicine (associate editor)、群馬大学大学院医学系研究科循環器内科学（客員教授）
個人のURL
担当科目 医療治療機器学、医用治療機器学実習、生体計測装置学
生理機能検査学I II、生理機能検査学実習 I II
体外循環装置学
臨床医学総論 I II
総合演習、卒業研究
ティーチング・
ポートフォリオ
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